I've been using Healthy Gut "Holoimmune" for about a 1.5 years now, and I definitely notice a difference in my overall health and feeling of well being; I have more energy and focus, my environmental allergies and histamine response(s) have greatly improved, and my gum recession is just now starting to show noticeable improvement, I also seem to respond and/or tolerate/navigate stress much better - A healthy gut equals a healthy immune response, and a healthy immune response equates to overall well being...