A powerful antioxidant that promotes the natural cell death of malignant cells. Also inhibits parasites, bacterial and viral infections. Supports healthy DNA. Studies show that edible berries may have potent chemo-preventive properties.

GreenMedInfo Research Abstract

National Library of Medicine Research Abstract

ScienceDirect.com Research Abstract

Anti-angiogenic property of edible berries

Effect of chemopreventive agents on DNA

Tannins, xenobiotic metabolism and cancer chemoprevention in experimental animals

The effects of dietary ellagic acid

p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells.

Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries.

DNA gyrase inhibitory activity of ellagic acid derivatives.

Antioxidant properties of novel preparations-bioflavonoid derivatives and tannins.

Human immunodeficiency virus type 1 cDNA integration: new aromatic hydroxylated inhibitors and studies of the inhibition mechanism.

Inhibitory actions of ellagic acid on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients.

Inhibition of liver fibrosis by ellagic acid.

The protective action of ellagic acid in experimental myocarditis

Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.

Antileishmanial activity of hydrolyzable tannins and their modulatory effects on nitric oxide and tumour necrosis factor-alpha release in macrophages in vitro..

Chemical studies of proanthocyanidins and hydrolyzable tannins.

Ellagitannins from Lagerstroemia speciosa as Activators of Glucose Transport in Fat Cells.

Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation.

IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid.

Experimental evidence for cancer preventive elements in foods.

Strong antioxidant activity of ellagic acid in mammalian cells

Chemical studies of proanthocyanidins and hydrolyzable tannins

Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties

p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells

3. Glutathione

Boosting levels of known antioxidant may help resist age-related decline

Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Performance in Triathlon Athletes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial

Free radicals, antioxidants and functional foods: Impact on human health

Glutathione and immune function

Glutathione and its antiaging and antimelanogenic effects

Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis

Glutathione Deficiency Research

Glutathione Depletion, Lipid Peroxidation and Mitochondrial Dysfunction Are Induced by Chronic Stress in Rat Brain

Glutathione dysregulation and the etiology and progression of human diseases

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

Glutathione pathways in the brain

Glutathione Research

Glutathione Upregulation Research

Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease

Mitochondrial Glutathione, a Key Survival Antioxidant

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

Oxidative stress and regulation of glutathione in lung inflammation

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study

Role of glutathione in immunity and inflammation in the lung

Science Direct: Glutathione

Science Direct: Glutathione by Editor in Chief

The importance of glutathione in human disease

The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis

Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency

Vitamin C elevates red blood cell glutathione in healthy adults

Boosting levels of known antioxidant may help resist age-related decline

Free radicals, antioxidants and functional foods: Impact on human health

Glutathione and immune function

Glutathione and its antiaging and antimelanogenic effects

Glutathione deficiency of the lower respiratory tract in patients with idiopathic pulmonary fibrosis

Glutathione Deficiency Research

Glutathione Depletion, Lipid Peroxidation and Mitochondrial Dysfunction Are Induced by Chronic Stress in Rat Brain

Glutathione dysregulation and the etiology and progression of human diseases

Glutathione Fine-Tunes the Innate Immune Response toward Antiviral Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties

Glutathione pathways in the brain

Glutathione Research

Glutathione Upregulation Research

Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease

Mitochondrial Glutathione, a Key Survival Antioxidant

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

Oxidative stress and regulation of glutathione in lung inflammation

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study

Role of glutathione in immunity and inflammation in the lung

Science Direct: Glutathione

Science Direct: Glutathione by Editor in Chief

The importance of glutathione in human disease

The role of the glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis

Vitamin C augments lymphocyte glutathione in subjects with ascorbate deficiency

Vitamin C elevates red blood cell glutathione in healthy adults

4. Hydrogen

All Degenerative Health Problems

Allergic Reactions Reduction (mast cell degranulation)

Autism Treatment with Hydrogen-rich Water

Auto Immune Disease

Blood cells

Brain Function and Moods

Brain Injury Treatment with Molecular Hydrogen

Cancer
http://www.ncbi.nlm.nih.gov/pubmed/19192719
http://www.ncbi.nlm.nih.gov/pubmed/18175936
http://www.ncbi.nlm.nih.gov/pubmed/22146004
Cardiovascular Disorders and Oxidative Stress

Cell and Tissue Protection from oxidative damage

Dementia and Neurological Diseases

Energy Increase

Eyes (retina)

Hearing
http://www.ncbi.nlm.nih.gov/pubmed/22387110
http://www.ncbi.nlm.nih.gov/pubmed/24945316
http://www.ncbi.nlm.nih.gov/pubmed/20888392
Insulin Resistance

Kidney

Liver
http://www.ncbi.nlm.nih.gov/pubmed/24127924
http://www.ncbi.nlm.nih.gov/pubmed/23682614
Lung tissue

Metabolic Syndrome Treatment

Multiple Sclerosis and Hydrogen-rich Water

Muscle Fatigue Reduction

Oral/ Periodontal
https://www.greenmedinfo.com/periodontitis
http://www.ncbi.nlm.nih.gov/pubmed/24985521
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4665424/
Pain from Inflammation

Pain (neuropathy)

Skin Heals Faster

Skin Wrinkle Improvement

5. Methylene Blue

Methylene Blue has a potent antiviral activity against SARS-CoV-2 and H1N1 influenza virus in the absence of UV-activation in vitro. Sci Rep 11, 14295 (2021), Cagno, V., Medaglia, C., Cerny, A. et al.

Repurposing methylene blue in the management of COVID-19 : Mechanistic aspects and clinical investigations. Biomed Pharmac other. 2021 Oct;142:112023. doi: 10.1016/j.biopha.2021.112023. Epub 2021 Aug 10. PMID: 34399199; PMCID: PMC8352658, Dabholkar N, Gorantla S, Dubey SK, Alexander A, Taliyan R, Singhvi G.

Methylene blue and its analogues as antidepressant compounds . Metab Brain Dis 32, 1357–1382 (2017), Delport, A., Harvey, B.H., Petzer, A. et al.

A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis . The British Journal of Psychiatry, 149(3), 353-356, Naylor, G. J., Martin, B., Hopwood, S. E., & Watson, Y. (1986).

Methylene blue reduces aß levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathology, 21(2), 140-149, Medina, D. X., Caccamo, A., & Oddo, S. (2011).

Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase. Journal of Alzheimer's Disease, 20(2), 439-452. PMID: 20463399, Atamna, H., & Kumar, R. (2010).

Methylene blue for distributive shock: a potential new use of an old antidote . Journal of Medical Toxicology, 9(3), 242-249, Jang, D. H., Nelson, L. S., & Hoffman, R. S. (2013).

From mitochondrial function to neuroprotection – an emerging role for methylene blue . Molecular Neurobiology, 55(6), 5137-5153, Tucker, D., Lu, Y., & Zhang, Q. (2018).

Methylene blue as an antimalarial agent . Redox Report, 8(5), 272-275, Schirmer, R. H., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., ... & Kouyaté, B. (2003).

Methylene Blue: An Antidote for Methemoglobinemia and Beyond. Pediatric Emergency Care, 37(9), 474-477, Mak, R. S. P., & Liebelt, E. L. (2021)

Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication . Clinical Toxicology, 56(9), 828-840, Haouzi, P., Gueguinou, M., Sonobe, T., Judenherc-Haouzi, A., Tubbs, N., Trebak, M., Cheung, J., & Bouillaud, F. (2018).

Acute respiratory distress syndrome from Covid-19: A perfect storm from free radicals? Proposal for a new treatment . Medical Hypotheses, 144, 110120, Scigliano, G., & Scigliano, G. A. (2020).

The delayed neuroprotective effect of methylene blue in experimental rat brain trauma. Antioxidants, 9(5), 377, Genrikhs, E. E., Stelmashook, E. V., Voronkov, D. N., Novikova, S. V., Alexandrova, O. P., Mironova, R. I., ... & Skrebitsky, V. G. (2020).

Methylene blue protects intestinal mucosa from free radical-mediated sublethal radiation damage. Free Radical Biology and Medicine, 5(4), 207-213, Hrushesky, W. J., Berestka, J. S., von Roemeling, R., Olshefski, R., Langevin, T. R., Potish, R. A., Delaney, J. P., Ellefson, M., & Schwartz, S. (1988).

Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes. Endocrine Research, 25(2), 163-171, Haluzik, M., Nedvídková, J., & Skrha, J. (1999).

Helicobacter pylori Eradication Using a Light-Emitting Diode and Methylene Blue. Laser Therapy , 27(1), 21-25, Ogasawara, K. (2018).

Methylene blue mediated photodynamic therapy for resistant plaque psoriasis . Journal of Drugs in Dermatology, 8(1), 42-49, Salah, M., Samy, N., & Fadel, M. (2009).

Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo. Emerging Microbes & Infections, 9(1), 2404-2416, Li, Z., Lang, Y., Sakamuru, S., Samrat, S., Trudeau, N., Kuo, L., ... & Xia, M. (2020).

A Reminder of Methylene Blue's Effectiveness in Treating Vasoplegic Syndrome after On-Pump Cardiac Surgery. Texas Heart Institute Journal, 42(5), 491-494, Manghelli, J., Brown, L., Tadros, H. B., & Munfakh, N. A. (2015).

New Twist on an Old Favorite: Gentian Violet and Methylene Blue Antibacterial Foams . Advances in Wound Care, 5(1), 11-18, Edwards, K. (2016).

SIRT1 activation by methylene blue, a repurposed drug , leads to AMPK-mediated inhibition of steatosis and steatohepatitis. European Journal of Pharmacology, 727, 115-124, Shin, S. Y., Kim, T. H., Wu, H., Choi, Y. H., & Kim, S. G. (2014).

Effect of methylene blue on the disposition of ethanol . Alcohol and Alcoholism, 35(5), 424-426, Vonlanthen, R., Beer, J. H., & Lauterburg, B. H. (2000).

Methylene Blue inhibits the inflammatory process of the acetic acid-induced colitis in the rat colonic mucosa. International Surgery, 100(7-8), 1166-1173, Dinc, S., Caydere, M., Akgul, G., Yenidogan, E., Hücümenoglu, S., & Rajesh, M. (2015).

Methylene blue inhibits the stimulation of bone mass by high doses of estradiol in male rats. Endocrine Regulations, 28(3), 141-144. PMID: 7589472, Broulik, P. D., & Schreiber, V. (1994).

ttenuation of noise-induced hearing loss using methylene blue. Cell Death & Disease, 5(4), e1200, Park, J. S., Jou, I., & Park, S. M. (2014).

Systemic anticancer therapy-induced peripheral and central neurotoxicity : ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct 1;31(10):1306-1319, Jordan B, Margulies A, Cardoso F, on behalf of the ESMO Guidelines Committee, the EONS Education Working Group, the EANO Guideline Committee.

A case for neuroprotection in ophthalmology : developments in translational research. Mo Med, 110(5), 429-36, Payne, A. J., Kaja, S., Sabates, N. R., & Koulen, P. (2013).

Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell, 15(2), 279-290, Xiong, Z. M., Choi, J. Y., Wang, K., Zhang, H., Tariq, Z., Wu, D., ... & Cao, K. (2016)

Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. Neuroscience, Volume 359, 2017, Pages 8-16, Elizabeth S Smith, Madeline E Clark, Gwendolyn A Hardy, David J Kraan, Elisa Biondo, F Gonzalez-Lima, Lawrence K Cormack, Marie Monfils, Hongjoo J Lee.

Methylene Blue Exerts Anticonvulsant and Neuroprotective Effects on Self-Sustaining Status Epilepticus (SSSE) Induced by Prolonged Basolateral Amygdala Stimulation in Wistar Rats. Med Sci Monit. 2018;24:161-169, Cui ZQ, Li WL, Luo Y, Yang JP, Qu ZZ, Zhao WQ.

Methylene blue treatment in experimental ischemic stroke : A mini-review. Brain Circulation, 2(1), 48–53, Jiang, Z., & Duong, T. Q. (2016).

Methylene blue relieves the development of osteoarthritis by upregulating lncRNA MEG3. Exp Ther Med. 2018 Apr;15(4):3856-3864, Li X, Tang C, Wang J, Guo P, Wang C, Wang Y, Zhang Z, Wu H.

Methylene blue and serotonin toxicity : Ramsay RR, Dunford C, Gillman PK., inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol. 2007 Nov;152(6):946-51

Methylene Blue as Antidote for Cyanide and Carbon Monoxide Poisoning

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