|
Mangosteen
Garcinia mangostana L.
Recently Published Information From the Sloan-Kettering Cancer Center in New York City:
CLINICAL SUMMARY
 Mangosteen
is a plant native to Southeast Asia. The fruits are used in traditional medicine
to treat skin infections, wounds, and diarrhea. Recent studies have revealed
that xanthones from the fruit hulls exhibit antibacterial (3), antifungal (4),
and antiinflammatory (5) properties. Alpha-mangostin, a xanthone, inhibited
growth of human leukemia HL60 cells (1) (6), reduced the synthesis of prostaglandins
(5), and prevented oxidative damage of LDL (7) in vitro. There is also preliminary
evidence that alpha- and gamma-mangostins act as histamine and serotonin receptor
blockers (8), and also inhibit HIV-1 protease (9). Garcinone E, another xanthone,
exerts cytotoxic effects against human hepatocellular carcinoma cells (10).
Extract from the pericarp of mangosteen has antiproliferative, antioxidative,
and apoptotic effects against human breast cancer SKBR3 cells (11). There is
no data from clinical trials to verify these effects in humans. No adverse effects
have been reported with the use of mangosteen.
PURPORTED USES
- Bacterial Infections
- Diarrhea
- Fungal infections
- Inflammation
- Skin infections
- Wound healing
CONSTITUENTS
Xanthones: alpha-mangostin, beta-mangostin, gamma-mangostin, garcinone B,
garcinone E, Mangostinone, Tannins
Flavonoid: epicatechin
MECHANISM OF ACTION
The xanthones, alpha- and beta-mangostins, and garcinone B exhibit
strong inhibitory effect against Mycobacterium tuberculosis in vitro
(3). Alpha-mangostin has been shown to inhibit growth of human
leukemia HL60 cells by inducing caspase-3-dependent apoptosis (1)
(6), reduce the synthesis of prostaglandins by inhibiting the
activities of COX-1 and COX-2 enzymes (5), and prevent oxidative
damage of LDL by functioning as a free-radical scavenger (7). Alpha-
and gamma-mangostins also antagonize the activities of histamine and
serotonin by acting as receptor blockers (8). Garcinone E has
cytotoxic effects against human hepatocellular carcinoma cells (10).
In vitro studies have also demonstrated that a crude methanolic
extract from the pericarp of mangosteen has antiproliferative,
antioxidative, and apoptotic effects against SKBR3 human breast
cancer cells (11).
www.mangosteenexperiences.com |
|
Friendly